Journal article
Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle
MRS Fortes, K Kemper, S Sasazaki, A Reverter, JE Pryce, W Barendse, R Bunch, R McCulloch, B Harrison, S Bolormaa, YD Zhang, RJ Hawken, ME Goddard, SA Lehnert
Animal Genetics | Published : 2013
DOI: 10.1111/age.12075
Abstract
A putative functional mutation (rs109231213) near PLAG1 (BTA14) associated with stature was studied in beef cattle. Data from 8199 Bos taurus, Bos indicus and Tropical Composite cattle were used to test the associations between rs109231213 and various phenotypes. Further, 23 496 SNPs located on BTA14 were tested for association with these phenotypes, both independently and fitted together with rs109231213. The C allele of rs109231213 significantly increased hip height, weight, net food intake, age at puberty in males and females and decreased IGF-I concentration in blood and fat depth. When rs109231213 was fitted as a fixed effect in the model, there was an overall reduction in associations ..
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Funding Acknowledgements
Northern Pastoral Group, Department of Employment, Economic Development and Innovation (DEEDI) and CSIRO Livestock Industries collaborated to collect phenotypes. We gratefully acknowledge those who measured traits and managed cattle, samples or data within the Beef CRC experiments. We thank Yuliaxis Ramayo Caldas for his contribution to the LD analysis. Funding support was received from the Australian Research Council's Discovery Projects funding scheme (project DP1093502).